Evaluation of Oxidative Potential of Pyrenequinone Isomers by the Dithiothreitol (DTT) Assay

Atmospheric quinoid polycyclic aromatic hydrocarbons (PAHQs) have adverse health effects as redox-active species in particulate matter (PM). Several PAHQs are known to be very reactive the dithiothreitol (DTT) assay; however, it is unclear if pyrenequinones, their parent pyrene one of most abundant (PAHs) atmosphere, contribute loss DTT PM extracts. Herein, by employing assay, we evaluated oxidative potentials three pyrenequinone isomers (4,5-pyrenequinone [4,5-PyQ] and a mixture 1,6-/1,8-pyrenequinones [1,6-/1,8-PyQ]), along with 9,10-phenanthrenequinone (PQN), 1,2-naphthoquinone (1,2-NQ), 1,4-naphthoquinone (1,4-NQ), which rates were examined previously. Our results demonstrate that consumption ortho-type fast, particularly 4,5-PyQ. The order rate tested this study was follows: 4,5-PyQ ? PQN > 1,2-NQ 1,4-NQ 1,6-/1,8-PyQ. confirmed active assay for first time study. 14.6 ± 0.8 mol/min/PAHQ-mol, comparable (14.4 0.1 mol/min/PAHQ-mol) so far.